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Filtered Search Results
Medchemexpress LLC FKBP12 PROTAC RC32 | 2375555-66-9 | 97.0% | 100 MG
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FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader that utilizes PROTAC technology. It is a conjugate of Rapamycin and a ligand for a Cereblon E3 ubiquitin ligase, designed to efficiently degrade FKBP12 protein.
- Potent degrader of FKBP12
- Based on PROTAC technology
- Contains conjugation of Rapamycin and a ligand for a Cereblon E3 ubiquitin ligase
- Efficiently degrades FKBP12 protein in most organs (in vivo studies)
- Induces FKBP12 protein degradation in human Jurkat cells (DC50 ~0.3 nM)
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Medchemexpress LLC Fkbp12 protac rc32 | 2375555-66-9 | 97.0% | 50 MG
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FKBP12 PROTAC RC32 is a potent FKBP12 degrader based on PROTAC technology. This degrader combines Rapamycin and a Cereblon E3 ubiquitin ligase ligand, Pomalidomide. It achieves approximately 50% protein degradation (DC50) of FKBP12 at 0.3 nM in Jurkat cells within 12 hours. In vivo, it effectively degrades FKBP12 in most organs of treated mice, Bama pigs, and rhesus monkeys, with oral administration also showing significant degradation in mice.
- Potent FKBP12 degrader based on PROTAC technology
- Composed of Rapamycin and a Cereblon E3 ubiquitin ligase ligand
- Achieves 50% protein degradation (DC50) of approximately 0.3 nM in Jurkat cells within 12 hours
- Degrades FKBP12 protein in most organs of treated mice (except brain)
- Efficiently degrades FKBP12 in various organs of Bama pigs and rhesus monkeys
- Effective with oral administration in mice
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Medchemexpress LLC Navocaftor | 2159103-66-7 | 99.2% | 416.33 | 10 MG
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Navocaftor is a protein modulator that acts as a cystic fibrosis transmembrane regulator (CFTR). It is intended for research use only. This compound has a high purity and exhibits specific solubility characteristics for various research applications.
- Solid appearance
- Light yellow to yellow color
- Purity of 99.20%
- Stable for 3 years at -20°C as powder
- Soluble in 10% DMSO, 90% corn oil for in vivo studies
- Acts as a cystic fibrosis transmembrane regulator (CFTR) protein modulator
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Medchemexpress LLC N-acetyltyramine | 1202-66-0 | 99.7% | 10 MG
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N-acetyltyramine is the N-acetyl derivative of the biogenic amine tyramine (CAS 1202-66-0). It is supplied for research use and has reported quorum-sensing inhibitory activity; analytical characterization and safety data are available.
- High purity: 99.7%.
- Available as solid packs including 10 mg and as a 10 mM solution in DMSO.
- Comprehensive analytical data available: COA, HPLC, LCMS, and NMR.
- CAS-registered compound for unambiguous identification.
- Intended for research use; consult SDS for handling and safety.
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Medchemexpress LLC BPR1M97 | 2059904-66-2 | 99.4% | 50 MG
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BPR1M97 is a dual-acting mu opioid receptor (MOP) and nociceptin-orphanin FQ peptide (NOP) receptor agonist. It has Ki values of 1.8 nM for MOP and 4.2 nM for NOP. BPR1M97 exhibits high potency, penetrates the blood-brain barrier, and produces potent antinociceptive effects. It is intended for research use only and is not sold to patients.
- Dual-acting mu opioid receptor (MOP) and nociceptin-orphanin FQ peptide (NOP) receptor agonist
- Ki values of 1.8 nM for MOP and 4.2 nM for NOP
- High potency
- Effective blood-brain barrier penetration
- Potent antinociceptive effects
- Intended for research use only
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![eMolecules 57031-66-0 | Ambeed | Methyl 1-methyl-1H-[124]triazole-3-carboxylate | 250mg | 588342297 | A282029 | MFCD13191558 | 141.13 | C5H7N3O2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502515874.JPG-250.jpg)
eMolecules 57031-66-0 | Ambeed | Methyl 1-methyl-1H-[124]triazole-3-carboxylate | 250mg | 588342297 | A282029 | MFCD13191558 | 141.13 | C5H7N3O2
Ambeed | Methyl 1-methyl-1H-[124]triazole-3-carboxylate | 250mg | 588342297 | A282029 | 57031-66-0 | MFCD13191558 | 141.130 | C5H7N3O2
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Medchemexpress LLC BODIPY-FL NHS ester | 146616-66-2 | 99.8% | 389.16 | 50 MG
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BODIPY FL NHS ester is a cell membrane-penetrable amine-reactive fluorescent probe with maximum excitation/emission wavelengths of 502/511 nm. It demonstrates high stability and is unaffected by polarity, pH, or solvent type, maintaining stable fluorescence across various environmental conditions.
- Can be utilized for the synthesis of protease substrates.
- Suitable for live cell imaging.
- Useful for protein labeling.
- Applicable in immunoassay.
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Medchemexpress LLC Navocaftor | 2159103-66-7 | 99.2% | 416.33 | 100 MG
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Navocaftor (GLPG 3067) is a cystic fibrosis transmembrane regulator (CFTR) and a protein modulator.
- Regulates cystic fibrosis transmembrane conductance.
- Modulates protein function.
- Store powder at -20°C for 3 years or 4°C for 2 years.
- Store in solvent at -80°C for 6 months or -20°C for 1 month.
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Medchemexpress LLC ML334 | 1432500-66-7 | 98.1% | 446.50 | 1 ML
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ML334 is a potent, cell-permeable activator of NRF2, functioning by inhibiting the Keap1-NRF2 protein-protein interaction. It binds to the Keap1 Kelch domain with a Kd of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation, leading to the induction of antioxidant response elements (ARE) activity.
- Potent, cell permeable activator of NRF2.
- Inhibits Keap1-NRF2 protein-protein interaction.
- Binds to Keap1 Kelch domain with a Kd of 1 μM.
- Stimulates NRF2 expression and nuclear translocation.
- Induces antioxidant response elements (ARE) activity.
- Increases NQO1 and TRX1 mRNAs in HEK293 cells.
- Enhances HO-1 mRNA expression in HEK293 cells.
- Induces HO-1 and TRX1 proteins in HEK293 cells.
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BIOHIPPO Research Grade Anti-Human FGF21 Biosimilar Antibody (CVX-343), 100 µg
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CVX-343 is a research-grade biosimilar antibody targeting FGF21. It reacts with Human. Suitable for ELISA, FACS, Functional assay, Research in vivo. This research-grade biosimilar supports comparability, functional, PK/PD and immunogenicity studies. Supplied as 100 ug.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000742026 5-METHOXYTRYPTAMINE- 1MG
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Ambeed AMBEED
5000887780 1-BOC-TRYPTAMINE 250MG
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eMolecules 1176749-66-8 | (1-methylindazol-5-yl)acetic acid | Synthonix | MFCD11901729 | 190.202 | C10H10N2O2 | 98.000 | Cn1ncc2cc(CC(O)=O)ccc12 | 100mg | 784551999
(1-methylindazol-5-yl)acetic acid | Synthonix | 1176749-66-8 | MFCD11901729 | 190.202 | C10H10N2O2 | 98.000 | Cn1ncc2cc(CC(O)=O)ccc12 | 100mg | 784551999
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Medchemexpress LLC Piromelatine | 946846-83-9 | MFCD30146157 | 99.5% | 312.32 g/mol | C17H16N2O4 | 5 MG
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Piromelatine is a multimodal neuropharmacological research compound acting as a melatonin MT1/MT2 receptor agonist, serotonin 5-HT1A/5-HT1D agonist, and 5-HT2B antagonist. It has been investigated for sleep-promoting, analgesic, anxiolytic, antidepressant, and potential neuroprotective effects. This material is supplied for laboratory research use only.
- Acts as a melatonin MT1/MT2 receptor agonist.
- Modulates serotonin receptors (5-HT1A/5-HT1D agonism, 5-HT2B antagonism).
- Reported to inhibit pain-related P2X3, TRPV1, and Nav1.7 channels.
- Molecular formula C17H16N2O4; molecular weight 312.32 g/mol.
- Recommended storage: 4°C for solid; protect from light; in solvent store at -80°C or -20°C.
- For research use only; not for human or clinical applications.
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![Medchemexpress LLC 4'-Acetyl-N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-[1,1'-biphenyl]-4-carboxamide | 162408-66-4 | MFCD00936840 | 99.9% | 485.62 g/mol | C30H35N3O3 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000213213.png-250.jpg)
Medchemexpress LLC 4'-Acetyl-N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-[1,1'-biphenyl]-4-carboxamide | 162408-66-4 | MFCD00936840 | 99.9% | 485.62 g/mol | C30H35N3O3 | 25 MG
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GR 103691 is a potent, selective dopamine D3 receptor antagonist (Ki = 0.4 nM) with more than 100-fold selectivity versus D4 and D1 receptors. It also shows affinity for 5-HT1A (Ki = 5.8 nM) and α-1 adrenoceptors (Ki = 12.6 nM). Supplied as a high-purity solid for research use.
- Potent D3 receptor antagonist (Ki = 0.4 nM).
- High selectivity for D3 over D4 and D1 receptors.
- Additional affinity for 5-HT1A and α-1 adrenoceptors.
- High reported purity (99.91%).
- Solid, white to off-white appearance suitable for handling and storage.
- Stable when stored as powder at -20°C for extended periods.
- Available in small milligram package sizes for preclinical research.
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